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Introduction
The use of Qnexa, a weight-loss drug, has raised concerns due to its potential side effects. One notable effect is elevated blood pressure, which is likely caused by its impact on the sympathetic nervous system, leading to tachycardia.
FDA’s Approach to Drug Approval
It is worth mentioning that the FDA is aware of these effects and is considering the need for further studies. However, they have decided that these studies will only be required after Qnexa is approved. While there may be some rationale behind this approach, the specific reasons remain unclear.
Short-Term Effects and Tolerance
Another concern is that the effects of phentermine, one of the drugs in Qnexa, only last a few weeks. After this period, users develop a tolerance to the drug. To maintain the effects, the dosage needs to be increased. However, increasing the dosage also raises the risk of dangerous side effects.
Topiramate: The Second Drug in Qnexa
The second drug in Qnexa is topiramate, originally developed as an anticonvulsant. The exact mechanism by which topiramate promotes weight loss is still unknown. Two leading theories suggest a loss of taste sensation or reduced cortisol production. Unfortunately, topiramate is associated with a long list of side effects, including dizziness, altered sensation, somnolence, diarrhea, nausea, depression, and fatigue. These side effects occur in more than 10% of users, which is significant.
Occurrence of Side Effects
The number of side effects occurring between 1-10% is even greater, and there are rarer side effects that could fill an entire paragraph.
Holistic Perspective
While it can be argued that the risk of these side effects decreases with time, it is important to consider that a drug capable of causing numerous side effects must be acting at a fundamental physiological level that researchers may not fully understand yet.
